ABSTRACT
Objective Based on CT imaging measurements to investigate the relevant parameters of 3D positioning that are used for the puncturing of trigeminal nerve via foramen rotundum route, and to discuss the influences of gender, age, and BMI on the measurements of these parameters in order to improve the success rate of puncturing. Methods A total of 64 patients with trigeminal neuralgia (second branch), who were successfully treated with CT - guided radiofrequency thermocoagulation of trigeminal nerve via foramen rotundum route during the period from August 2015 to March 2017, were included in this study. Their CT images were retrospectively analyzed. The line from the opening of the external auditory canal to the root of the nose (ear-nose line) was used as the base line on sagittal plane, and the angle between the ear-nose line and the puncture needle (angle α) was measured. On transverse section drawing a line between the midpoint of nose bridge and the midpoint of the posterior edge of the ethmoid sinus (M line), the angle between M line and the puncture needle (angle β) was determined. The vertical distance from the midpoint of the foramen rotundum to M line(D1), the vertical distance from needle puncture point to M line(D2), and the puncture depth (D3) were respectively measured. Results The angle α varied from 44. 10° to 63. 50° with a mean of (55. 05°±5. 48°). The angle β ranged from 26. 42° to 68. 37° with an average of (38. 19°±8. 58°). The distance of D1 was (19. 55±2. 67) mm, the distance of D2 was (58. 50±5. 41) mm, and the depth of D3 was (64. 89+8. 21) mm. The gender, age and BMI value showed a close correlation with the puncture angle and the puncture depth (P＜0. 05), and no statistically significant differences in these indexes existed between the left side and the right side (P＞0. 05). Conclusion The angle a and the other puncture parameters can roughly determine the three dimensional spatial orientation of foramen rotundum, which can be further adjusted according to patient's gender, age and BMI value. (J Intervent Radiol, 2018, 27: 234-237)
ABSTRACT
Objective To investigate the clinical efficacy and toxicity of patients with advanced non-small cell lung cancer(NSCLC) treated with weekly dose doctaxale. Methods 50 elderly cases with histologically or cytologically diagnosed advanced NSCLC were treated in treatment group(n=28) ,using docetaxel(at a dose of 35mg/m2 infused on day 1 and 8,21 days as one cycle). Control group (n=22) , using best supportive care (BSC). Results The response rate 32. 0% in treatment group were significantly higher than 10. 0% in control group(x2=8. 156, P＜0.01) ;The median time to tumor progression (TTP) , median survival(OS) ,1-year survival rate(6. 0month,12. 5 month,40. 1%) in treatment group were significantly higher(2. 5month,5. 2 month, 10. 3%) than those in control group(x2=7.234,7. 812,8.989,all P＜0.01) ;The KPS score(89.5 ±10.2)points after treatment were higher than the control group after treatment (76. 0 ± 9. 9) points which was significantly different (t =2. 330, P＜0. 05); The score of LCSS in cough,hemoptysis,chest pain,shortness of breath[(92.4 ±16.9) points, (93.4 ±17.5) points]after treatment,were significantly higher than the control group[(82. 4 ± 15. 0) points, (81. 3 ± 16. 0) points] which were significantly different(t = 2. 2150,2.245, all P＜0. 05). Conclusion The weekly dose doctaxale was a feasible , well-tolerated, and active scheme in the treatment of elderly patients with advanced NSCLC.
ABSTRACT
OBJECTIVE:To observe the preventive effect of Ca/Mg infusion combined with glutathione and carbamazepine on oxaliplatin-induced neurotoxicity.METHODS:65patients treated with oxaliplatin,5-fluorouracil and leucovorin for gas-trointestinal cancer were divided into treatment group undergoing treatment with Ca/Mg infusion combined with glutathione and carbamazepine,and control group without any preventive treatment.RESULTS:At the third cycle,7patients in the treat-ment group but17patients in the control group showed clinically evident neurotoxicity,which demonstrated the statistical difference between the two groups(P=0.036).After12cycles,neurotoxicity of grade2to3was observed in2patients in the treatment group but in9patients in the control group,which demonstrated the statistical difference between the two groups(P=0.022).CONCLUSION:Ca/Mg infusions combined with glutathione and carbamazepine can prevent oxaliplatin-induced neurotoxicity.